Parkinson Disease

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CBD Beneficial Effects on Parkinson's, Alzheimer's & MS Last Updated on 2017-07-24 13:28:36 Mannucci C1, Navarra M1, Calapai F1, Spagnolo EV2, Busardò FP3, Da Cas R4, Ippolito FM4, Calapai G1.   Cannabidiol (CBD) is among the major secondary metabolites of Cannabis devoid of the delta-9-tetra-hydrocannabinol psychoactive effects. It is a resorcinol-based compound with a broad spectrum of potential therapeutic properties, including neuroprotective effects in numerous pathological conditions. CBD neuroprotection is due to its antioxidant and antiinflammatory activi-ties and the modulation of a large number of brain biological targets (receptors, channels) involved in the development and maintenance of neurodegenerative diseases. Aim of the present review was to describe the state of art about the pre-clinical research, the potential use and, when existing, the clinical evidence related to CBD in the neurological field. Collection of all the... More »
Parkinson's Disease - Patients Improved Quality of Life Last Updated on 2017-07-18 18:55:41 VIDEO Patient Taylor French before and after CBD treatments for Parkinson's Disease More »
Parkinson's Patient Finds Better Quality of Life Last Updated on 2017-07-18 18:54:40 VIDEO   More »
Medical Marijuana: A Breakthrough for Parkinson's? Last Updated on 2017-07-18 18:48:29 According to the National Institutes of Health (NIH), Parkinson's disease is a progressive neurodegenerative disorder that destroys dopaminergic neurons. This affects movement, muscle control, balance, and other functions. It is classified as part of a group of conditions known as motor systems disorders. Recently, the use of medical marijuana has received much attention as a leading alternative therapy for Parkinson's disease. The discovery of cannabis as a treatment for Parkinson's dates back to the late 1800's.William Gowers found that "Indian Hemp" (cannabis) helped with tremors in Parkinson's patients. Of the power of cannabis and opium in combination, he stated, "I have several times seen a very distinct improvement for a considerable time under their use." It wasn't until the 21st century that cannabis was reintroduced as an... More »
Endocannabinoids - Implications for Parkinson Disease Last Updated on 2017-07-18 18:41:14 Endocannabinoids are endogenous lipid messengers that bind the cannabinoid (CB) receptors. These receptors mediate the multiple behavioral effects of l-Δ9 tetrahydrocannabinol, the main psychoactive component of marijuana (cannabis). The endocannabinoid system has been implicated in a large variety of functions, including regulation of appetite and energy metabolism, pain and inflammation, neuroprotection, and modulation of basal ganglia circuits.1 Not surprisingly, the endocannabinoid system has raised great interest as a potential pharmacologic target from management of disorders such as obesity, pain, nausea, and neurologic conditions such as multiple sclerosis and movement disorders. The aim of this article is to briefly review some basic concepts on the biochemistry, pharmacology, and synaptic modulatory role of the endocannabinoid system with focus on the basal ganglia... More »