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CBD suppress inflammation and pain by targeting receptors Last Updated on 2017-07-24 15:55:20 source: The Rockefeller University Press   Wei Xiong,1 Tanxing Cui,3,4,5 Kejun Cheng,2 Fei Yang,6 Shao-Rui Chen,7 Dan Willenbring,3,4,5 Yun Guan,6 Hui-Lin Pan,7 Ke Ren,8 Yan Xu,3,4,5 and Li Zhang1 Author information ► Article notes ► Copyright and License information ► This article has been cited by other articles in PMC.   Go to: Abstract Certain types of nonpsychoactive cannabinoids can potentiate glycine receptors (GlyRs), an important target for nociceptive regulation at the spinal level. However, little is known about the potential and mechanism of glycinergic cannabinoids for chronic pain treatment. We report that systemic and intrathecal administration of cannabidiol (CBD), a major nonpsychoactive component of marijuana, and its modified derivatives significantly suppress chronic inflammatory and neuropathic pain without causing apparent... More »
Medical Abstract - CBD & Inflammation Last Updated on 2017-07-13 17:08:59 2016 Nov 24;7:559. eCollection 2016. Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Libro R1, Scionti D1, Diomede F2, Marchisio M3, Grassi G4, Pollastro F5, Piattelli A2, Bramanti P1, Mazzon E1, Trubiani O2. Author information Abstract Human Gingival Mesenchymal Stem Cells (hGMSCs) are multipotential cells that can expand and differentiate in culture under specific and standardized conditions. In the present study, we have investigated whether in vitro pre-treatment of hGMSCs with Cannabidiol(CBD) can influence their expression profile, improving the therapeutic potential of this cell culture. Following CBD treatment (5 μM) for 24 h, gene expression analysis through Next Generation Sequencing (NGS) has revealed several genes differentially expressed between CBD-treated hGMSCs (CBD-hGMSCs) and... More »
Topical cannabinoids may help to treat skin diseases Last Updated on 2017-06-22 13:36:47 Cannabinoids - a class of chemicals found in cannabis - may be effective as a topical treatment for an array of skin diseases, including psoriasis, severe itching, and atopic and contact dermatitis. This is the conclusion of a new review by researchers from the University of Colorado. The team also noted a link between injection with tetrahydrocannabinol (THC) - the psychoactive compound in cannabis - and a reduction in tumor growth in mice with melanoma, the deadliest form of skin cancer. Senior study author Dr. Robert Dellavalle, associate professor of dermatology at the University of Colorado School of Medicine, recently published their findings in the Journal of the American Academy of Dermatology. In the United States, cannabis is becoming increasingly legalized for medicinal purposes, including for the treatment of nausea, pain, and inflammation. A number of studies have also... More »
Inflammation Last Updated on 2017-06-14 15:38:20 Inflammation J Neuroinflammation. 2015 Mar 15;12:52. doi: 10.1186/s12974-015-0273-0. Cannabidiol, a non-psychoactive cannabinoid, leads to EGR2-dependent anergy in activated encephalitogenic T cells. Kozela E1, Juknat A2, Kaushansky N3, Ben-Nun A4, Coppola G5, Vogel Z6,7. Author information Abstract BACKGROUND: Cannabidiol (CBD), the main non-psychoactive cannabinoid, has been previously shown by us to ameliorate clinical symptoms and to decrease inflammation in myelin oligodendrocyte glycoprotein (MOG)35-55-induced mouse experimental autoimmune encephalomyelitis model of multiple sclerosis as well as to decrease MOG35-55-induced T cell proliferation and IL-17 secretion. However, the mechanisms of CBD anti-inflammatory activities are unclear. METHODS: Here we analyzed the effects of CBD on splenocytes (source of accessory T cells and antigen presenting cells (APC)) co-cultured... More »