Skin Disease

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FDA Notice Calls CBD "Beneficial" Last Updated on 2017-08-23 19:35:25 Cannabis Business Times | August 21st 2017 | Melissa Schiller In an Aug. 14 notice requesting public comments for a UN drug committee, the U.S. Food and Drug Administration (FDA) said CBD was the only beneficial substance on the international committee’s list of 17 substances under review. In the descriptions of the substances under review, the FDA stated, “CBD has been shown to be beneficial in experimental models of several neurological disorders, including those of seizure and epilepsy. In the United States, CBD-containing products are in human clinical testing in three therapeutic areas, but no such products are approved by FDA for marketing for medical purposes in the United States.” The notice goes on to say that CBD is a Schedule I controlled substance under the Controlled Substances Act (CSA). The FDA is looking for public input on CBD’s (and the... More »
Inhibition of skin tumor growth by activation of cannabinoid receptors. Last Updated on 2017-07-18 18:16:51 Casanova ML1, Blázquez C, Martínez-Palacio J, Villanueva C, Fernández-Aceñero MJ, Huffman JW, Jorcano JL, Guzmán M.   Nonmelanoma skin cancer is one of the most common malignancies in humans. Different therapeutic strategies for the treatment of these tumors are currently being investigated. Given the growth-inhibiting effects of cannabinoids on gliomas and the wide tissue distribution of the two subtypes of cannabinoid receptors (CB(1) and CB(2)), we studied the potential utility of these compounds in anti-skin tumor therapy. Here we show that the CB(1) and the CB(2) receptor are expressed in normal skin and skin tumors of mice and humans. In cell culture experiments pharmacological activation of cannabinoid receptors induced the apoptotic death of tumorigenic epidermal cells, whereas the viability of nontransformed epidermal cells... More »
Is CBD the Next Big Thing for Acne? Last Updated on 2017-07-18 14:10:28 Leafly | Joe Wilson | July 10th 2017 Blackheads? Zits? Say goodbye to acne with a brand new cure—synthetic cannabis! That, at least, is the hope of Botanix Pharmaceuticals Ltd., a dermatological company that just announced the completion of its Phase 1 clinical trial for an acne drug that incorporates synthetic cannabidiol (CBD). Called BTX 1503, the goal is that the drug could one day be an answer to acne. What Are Cannabis Topicals and How Do They Work? Botanix began clinical trials of the drug in Australia last year. Twenty participants, all without acne symptoms, applied the synthetic cannabinoid-based topical over the course of a month to test its safety, tolerability, and pharmacokinetics (the amount of the drug detectable in the bloodstream after use). The company plans to start a pilot program for acne patients later this quarter. Clinical trials tend to be... More »
CBD Helps Acne Last Updated on 2017-07-18 14:00:25 The Journal of Clinical Investigation  |  July 25 2014 source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151231/ Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes Attila Oláh,1 Balázs I. Tóth,1,2 István Borbíró,1 Koji Sugawara,3,4 Attila G. Szöllõsi,1 Gabriella Czifra,1 Balázs Pál,5Lídia Ambrus,1 Jennifer Kloepper,4 Emanuela Camera,6 Matteo Ludovici,6 Mauro Picardo,6 Thomas Voets,2 Christos C. Zouboulis,7 Ralf Paus,4,8 and Tamás Bíró1 Author information ► Article notes ► Copyright and License information ► This article has been cited by other articles in PMC.   Go to: Abstract The endocannabinoid system (ECS) regulates multiple physiological processes, including cutaneous cell growth and differentiation. Here, we... More »
Topical cannabinoids may help to treat skin diseases Last Updated on 2017-06-22 13:36:47 Cannabinoids - a class of chemicals found in cannabis - may be effective as a topical treatment for an array of skin diseases, including psoriasis, severe itching, and atopic and contact dermatitis. This is the conclusion of a new review by researchers from the University of Colorado. The team also noted a link between injection with tetrahydrocannabinol (THC) - the psychoactive compound in cannabis - and a reduction in tumor growth in mice with melanoma, the deadliest form of skin cancer. Senior study author Dr. Robert Dellavalle, associate professor of dermatology at the University of Colorado School of Medicine, recently published their findings in the Journal of the American Academy of Dermatology. In the United States, cannabis is becoming increasingly legalized for medicinal purposes, including for the treatment of nausea, pain, and inflammation. A number of studies have also... More »